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John A Barnard, MD
Professor of Pediatrics
Department of Pediatrics (Nationwide Children's Hospital)
College of Medicine
The Ohio State University
John A. Barnard, MD, is President of The Research Institute at Nationwide Children’s Hospital and Vice-Chair for Research in the Department of Pediatrics. He is a Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Barnard’s NIH-funded research program focuses on regulation of intestinal epithelial growth by transforming growth factor beta. Dr. Barnard is immediate past-president of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and has been named among the Best Doctors in America since 2003.

The Barnard laboratory, funded by an R01 from NIDDK, is dedicated to understanding the protein effects of TGFß in intestinal epithelial biology. Generally, we use in vitro cell culture models and genetically modified mice to dissect out signaling pathways involved in Smad-dependent and Smad independent signaling, and tumor suppressive signaling from pro-oncogenic signaling. Currently we are characterizing the role of the ZAS transcription factor family in Smad-dependent signaling and are characterizing a fascinating phenotype observed in transgenic mouse lines expressing mutant, constitutively active TGFß1 under direction of the intestine-specific villin promoter. The mice will be used to study pro-oncogenic and tumor suppressive TGFß activities in mouse models of intestinal neoplasia.

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