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Cancer Genetics

Hodgkin`s Lymphoma



Please discuss genetic aspects of Hodgkin`s Lymphoma in a 22-year-old female. What is the increased risk of a sibling developing this? Is it likely to recur after chemo and radiation (Stage IIa)?


As with many other cancers, the factors that cause Hodgkin`s disease (HD) may be genetic, environmental, or a combination of both. Occasionally, several occurrences of HD have been seen within the same family. Most of the time, however, HD will not recur within the same family. First-degree relatives (parents, children, siblings) of individuals with HD appear to have only a slightly increased risk for developing HD themselves.

In the 1997 textbook, Cancer:Principles and Practice of Oncology, the authors state that patients with Stage I or IIA HD have a 70-80% freedom from relapse rate over a 10 to 20 year period. This only applies to individuals who have had HD staging using laparoscopy and whose treatment consists of subtotal lymphoid irradiation and multiagent chemotherapy (if necessary).

If you wish further information on Hodgkin's disease, try the National Cancer Institute's web site.

Related Resources:

Support group for individuals with HD
National Cancer Institute
PDQ-NCI's Comprehensive Cancer Database

For more information:

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Response by:

Heather L Hampel, MS, CGC Heather L Hampel, MS, CGC
Cancer Genetic Counselor
College of Medicine
The Ohio State University

Judith A Westman, MD Judith A Westman, MD
Associate Professor, Clinical Internal Medicine, Pediatrics and Medical Biochemistry
College of Medicine
The Ohio State University