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Prostate Cancer

PSA 134 - 138

07/14/2011

Question:

Biopsy shows prostate cancer. Doctor questions why PSA is 134 - 138 but MRI does not show cancer anywhere else. Enlarged bladder? Could this be the cause?

Answer:

Prostate cancer associated with PSA > 20 ng/ml should be further investigated with Nuclear Medicine bone scan and CT (or MRI) imaging of the abdomen and pelvis. The extremely elevated PSA may reflect spread to either lymph nodes (CT or MRI) and/or bone (NM bone scan). Other causes of extreme elevation of PSA may include inflammation (prostatitis either spontaneous or due to trauma of biopsy) or enlarged prostate. Enlargement of the bladder plays no role in PSA values.

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Response by:

James F Donovan, Jr, MD James F Donovan, Jr, MD
Professor of Surgery
Director of UC Urology
College of Medicine
University of Cincinnati